E-ISSN 2305-1620 | ISSN 2221-0288
 
2025, Vol: 15, Issue: 1
15 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles
Required files to be uploaded

Title page (Sample)

Case Report
Online Published: 10 Jan 2025
 


Initial clinical experience with indigenously produced [177Lu]Lu-DOTA-TATE in small bowel carcinoid tumor - a case report

Sabeen Zia, Aakif Ullah Khan, Nadeem Ahmad Lodhi, Hameedullah, Irfan Ullah, Maria Ashfaq.


Abstract
Background: Carcinoids are slow-growing neuroendocrine tumors that can be found throughout the gastrointestinal tract and in other organs like the lungs and kidneys. These tumors are capable of metastasis and production of certain chemicals, e.g., serotonin that can cause carcinoid syndrome. Initial treatment is surgery; however, inoperable or metastatic carcinoid tumors can be treated with peptide receptor radionuclide therapy using [177Lu]Lu-DOTA-TATE which can provide symptomatic relief and also slows the disease progression.
Case presentation: We present here a case of gastrointestinal carcinoid in a 65-year-old male patient treated with indigenously produced [177Lu]Lu-DOTA-TATE. The patient presented 3 years after the resection of the intestinal mass and was on somatostatin analogues for control of flushing and diarrhea. Investigations revealed a focal lesion in the liver for which [177Lu]Lu-DOTA-TATE therapy was planned. The patient underwent four cycles of [177Lu]Lu-DOTA-TATE therapy with no undesirable side effects. Six months follow-up investigations after the completion of four cycles of [177Lu]Lu-DOTA-TATE therapy showed no interval progression and a better control of symptoms.
Conclusion: [177Lu]Lu-DOTA-TATE therapy is an effective but expensive treatment for patients having symptomatic disease and inoperable or progressive neuroendocrine tumors; that do not respond well to conventional treatments. Until recently, [177Lu] Lu-DOTA-TATE had to be imported for use in such patients which increased its cost even more. However, the initiative for the production of this radio-pharmaceutical in Pakistan has made it easier to acquire and also lowered the cost significantly.

Key words: PRRT, [177Lu]Lu-DOTA-TATE therapy, neuroendocrine tumors, small bowel carcinoid.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sabeen Zia
Articles by Aakif Ullah Khan
Articles by Nadeem Ahmad Lodhi
Articles by Hameedullah
Articles by Irfan Ullah
Articles by Maria Ashfaq
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Zia S, Khan AU, Lodhi NA, Hameedullah , Ullah I, Ashfaq M. Initial clinical experience with indigenously produced [177Lu]Lu-DOTA-TATE in small bowel carcinoid tumor - a case report. Pak J Nucl Med. 2024; 14(1): 30-33. doi:10.24911/PJNMed.175-1727608907

Web Style

Zia S, Khan AU, Lodhi NA, Hameedullah , Ullah I, Ashfaq M. Initial clinical experience with indigenously produced [177Lu]Lu-DOTA-TATE in small bowel carcinoid tumor - a case report. https://www.pjnmed.com/?mno=222437 [Access: June 29, 2026]. doi:10.24911/PJNMed.175-1727608907

AMA (American Medical Association) Style

Zia S, Khan AU, Lodhi NA, Hameedullah , Ullah I, Ashfaq M. Initial clinical experience with indigenously produced [177Lu]Lu-DOTA-TATE in small bowel carcinoid tumor - a case report. Pak J Nucl Med. 2024; 14(1): 30-33. doi:10.24911/PJNMed.175-1727608907


Vancouver/ICMJE Style

Zia S, Khan AU, Lodhi NA, Hameedullah , Ullah I, Ashfaq M. Initial clinical experience with indigenously produced [177Lu]Lu-DOTA-TATE in small bowel carcinoid tumor - a case report. Pak J Nucl Med. (2024), [cited June 29, 2026]; 14(1): 30-33. doi:10.24911/PJNMed.175-1727608907


Harvard Style

Zia, S., Khan, . A. U., Lodhi, . N. A., Hameedullah, ., Ullah, . I. & Ashfaq, . M. (2024) Initial clinical experience with indigenously produced [177Lu]Lu-DOTA-TATE in small bowel carcinoid tumor - a case report. Pak J Nucl Med, 14 (1), 30-33. doi:10.24911/PJNMed.175-1727608907


Turabian Style

Zia, Sabeen, Aakif Ullah Khan, Nadeem Ahmad Lodhi, Hameedullah, Irfan Ullah, and Maria Ashfaq. 2024. Initial clinical experience with indigenously produced [177Lu]Lu-DOTA-TATE in small bowel carcinoid tumor - a case report. Pakistan Journal of Nuclear Medicine, 14 (1), 30-33. doi:10.24911/PJNMed.175-1727608907


Chicago Style

Zia, Sabeen, Aakif Ullah Khan, Nadeem Ahmad Lodhi, Hameedullah, Irfan Ullah, and Maria Ashfaq. "Initial clinical experience with indigenously produced [177Lu]Lu-DOTA-TATE in small bowel carcinoid tumor - a case report." Pakistan Journal of Nuclear Medicine 14 (2024), 30-33. doi:10.24911/PJNMed.175-1727608907


MLA (The Modern Language Association) Style

Zia, Sabeen, Aakif Ullah Khan, Nadeem Ahmad Lodhi, Hameedullah, Irfan Ullah, and Maria Ashfaq. "Initial clinical experience with indigenously produced [177Lu]Lu-DOTA-TATE in small bowel carcinoid tumor - a case report." Pakistan Journal of Nuclear Medicine 14.1 (2024), 30-33. Print. doi:10.24911/PJNMed.175-1727608907


APA (American Psychological Association) Style

Zia, S., Khan, . A. U., Lodhi, . N. A., Hameedullah, ., Ullah, . I. & Ashfaq, . M. (2024) Initial clinical experience with indigenously produced [177Lu]Lu-DOTA-TATE in small bowel carcinoid tumor - a case report. Pakistan Journal of Nuclear Medicine, 14 (1), 30-33. doi:10.24911/PJNMed.175-1727608907




Most Viewed Articles
Most Accessed Articles

  • Determination of the optimum filter for 99mTc SPECT breast imaging using a wire mesh collimator
    Xianling Dong, M I Saripan, R Mahmud, S Mashohor, Aihui Wang
    Pak J Nucl Med. 2017; 7(1): 9-15
    » Abstract » doi: 10.24911/PJNMed.7.2

  • Behaviour of wedges for different field sizes and depths
    Sajjad Ahmed Memon, Naeem Ahmed Laghari, Fayaz Hussain Mangi
    Pak J Nucl Med. 2017; 7(1): 20-27
    » Abstract » doi: 10.24911/PJNMed.7.4

  • Clinical characteristics and long-term outcome of patients with differentiated carcinoma of thyroid with bone metastases: a retrospective study
    Sadaf Tufail Butt, Shazia Fatima, Noreen Marwat, Kahkashan Mir, Ayesha Ammar, Mohammad Faheem
    Pak J Nucl Med. 2017; 7(1): 34-37
    » Abstract » doi: 10.24911/PJNMed.7.6

  • Pre-operative cardiac risk stratification for noncardiac surgery in cancer patients using myocardial perfusion scintigraphy
    Iqbal Munir, Amrah Javaid, Khalid Nawaz, Mohammed Hathaf Al-Rowaily, Muaadh Abdualrehman Al-Asbahi
    Pak J Nucl Med. 2017; 7(1): 28-33
    » Abstract » doi: 10.24911/PJNMed.7.5

  • A brief review of targetted radionuclide therapies
    Mohammed Hathaf Al-Rowaily, Daniele Dondi, MarcoChinol, Iqbal Munir, Muaadh Abdualrehman Alasbahi
    Pak J Nucl Med. 2017; 7(1): 4-8
    » Abstract » doi: 10.24911/PJNMed.7.1

    •
    Most Downloaded
    Top Downloaded Articles

  • Behaviour of wedges for different field sizes and depths
    Sajjad Ahmed Memon, Naeem Ahmed Laghari, Fayaz Hussain Mangi
    Pak J Nucl Med. 2017; 7(1): 20-27
    » Abstract » doi: 10.24911/PJNMed.7.4

  • Determination of the optimum filter for 99mTc SPECT breast imaging using a wire mesh collimator
    Xianling Dong, M I Saripan, R Mahmud, S Mashohor, Aihui Wang
    Pak J Nucl Med. 2017; 7(1): 9-15
    » Abstract » doi: 10.24911/PJNMed.7.2

  • Characterization of SIEMENS Symbia T SPECT camera in Monte Carlo simulation environment
    Xianling Dong, Mahmud Iqbal Saripan, Rozi Mahmud, Syamsiah Mashohor, Aihui Wang,
    Pak J Nucl Med. 2018; 8(1): 18-26
    » Abstract » doi: 10.24911/PJNMed.175-1540569779

  • A historic review of the discovery of the medical uses of radioiodine
    Barbara Hertz, Pushan Bharadwaj, Bennett Greenspan
    Pak J Nucl Med. 2020; 10(1): 60-63
    » Abstract » doi: 10.24911/PJNMed.175-1582813482

  • A brief review of targetted radionuclide therapies
    Mohammed Hathaf Al-Rowaily, Daniele Dondi, MarcoChinol, Iqbal Munir, Muaadh Abdualrehman Alasbahi
    Pak J Nucl Med. 2017; 7(1): 4-8
    » Abstract » doi: 10.24911/PJNMed.7.1

    •

    About Pakistan Journal of Nuclear Medicine

    The Pakistan Journal of Nuclear Medicine (PJNM) is the official journal of the Pakistan Society of Nuclear Medicine and the first nuclear medicine journal ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Address: Pakistan Journal of Nuclear Medicine (PJNM), Room # D-115, D-Block, Department of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, 45650, Pakistan.

    Email: pjnm@pieas.edu.pk, Phone: +92 51 9248706, Fax: +92 51 9248600

    Title Owner: Pakistan Society of Nuclear Medicine

    https://psnmed.com/

    Society Email: secretary@psnmed.com

    Address: Institute of Nuclear Medicine & Oncology (INMOL), New Campus Road, Lahore, Pakistan.

    Contact the publisher:

    contact@discoverpublish.com

    https://discoverpublish.com/ 

    Address: Discover STM Publishing Ltd, 82 Leslie's Arch, Old Quarter, Ballincollig, Cork, P31 RY62, Ireland.

    Hours:  M-F: 8:30am - 5:30pm

    Contact Emails:

    Journal Editorial Office: contact@pjnmed.com

    Billing Support:  contact@discoverpublish.com

    Technical Support: anastasiia.pavlenco@sofiafields.com - https://sofiafields.com/ 


     
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information