E-ISSN 2305-1620 | ISSN 2221-0288
 

Original Article 


Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex <sup>99m</sup>Tc-Methotrexate

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba.


Abstract
Objective: Methotrexate (MTx) is an anticancer agent used in the treatment of various cancers. The objective of this study was to document the biodistribution of <sup>99m</sup>Tc-labelled Mtx (<sup>99m</sup>Tc-MTx) in normal subjects and patients with breast cancers. <br><br> Methods: We prepared the <sup>99m</sup>Tc-MTx kit by a direct labelling method and studied its biodistribution in volunteer subjects and patients with breast carcinoma breast. This clinical study was preceded by animal trials. <br><br> Results: The normal biodistribution pattern in humans was characterized by nonspecific uptake in the body with the <sup>99m</sup>Tc-MTx behaving like a blood pool agent with no evidence of specific organ uptake. The kidneys were seen to be the main route of excretion. Biodistribution data of patients with carcinoma breast showed excellent tracer uptake in the tumour and showed no other nonspecific tracer uptake. <br><br> Conclusion: This initial clinical trial showed that <sup>99m</sup>Tc-labelled anticancer drug can be successfully used for tumour scintigraphy, which appears to be a major breakthrough as this method of labelling and scanning may be useful in future tumour staging, calculating the sensitivity of tumours to certain anticancer agent and response evaluation during chemotherapy.


 
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Pubmed Style

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba. Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pak J Nucl Med. 2013; 3(1): 37-43.


Web Style

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba. Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. https://www.pjnmed.com/?mno=284647 [Access: February 28, 2024].


AMA (American Medical Association) Style

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba. Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pak J Nucl Med. 2013; 3(1): 37-43.



Vancouver/ICMJE Style

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba. Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pak J Nucl Med. (2013), [cited February 28, 2024]; 3(1): 37-43.



Harvard Style

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba (2013) Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pak J Nucl Med, 3 (1), 37-43.



Turabian Style

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba. 2013. Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pakistan Journal of Nuclear Medicine, 3 (1), 37-43.



Chicago Style

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba. "Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate." Pakistan Journal of Nuclear Medicine 3 (2013), 37-43.



MLA (The Modern Language Association) Style

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba. "Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate." Pakistan Journal of Nuclear Medicine 3.1 (2013), 37-43. Print.



APA (American Psychological Association) Style

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba (2013) Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pakistan Journal of Nuclear Medicine, 3 (1), 37-43.





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