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Original Article 


Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate

Sajjad Ahmed Memon, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, Shahid Iqba.


Abstract
Objective: Methotrexate (MTx) is an anticancer agent used in the treatment of various cancers. The objective of this study was to document the biodistribution of 99mTc-labelled Mtx (99mTc-MTx) in normal subjects and patients with breast cancers.

Methods: We prepared the 99mTc-MTx kit by a direct labelling method and studied its biodistribution in volunteer subjects and patients with breast carcinoma breast. This clinical study was preceded by animal trials.

Results: The normal biodistribution pattern in humans was characterized by nonspecific uptake in the body with the 99mTc-MTx behaving like a blood pool agent with no evidence of specific organ uptake. The kidneys were seen to be the main route of excretion. Biodistribution data of patients with carcinoma breast showed excellent tracer uptake in the tumour and showed no other nonspecific tracer uptake.

Conclusion: This initial clinical trial showed that 99mTc-labelled anticancer drug can be successfully used for tumour scintigraphy, which appears to be a major breakthrough as this method of labelling and scanning may be useful in future tumour staging, calculating the sensitivity of tumours to certain anticancer agent and response evaluation during chemotherapy.


 
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How to Cite this Article
Pubmed Style

Memon SA, Laghari NA, Qureshi ST, Ahmad F, Masood A, Iqba S. Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pak J Nucl Med. 2013; 3(1): 37-43.

Web Style

Memon SA, Laghari NA, Qureshi ST, Ahmad F, Masood A, Iqba S. Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. https://www.pjnmed.com/?mno=284647 [Access: June 29, 2026].

AMA (American Medical Association) Style

Memon SA, Laghari NA, Qureshi ST, Ahmad F, Masood A, Iqba S. Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pak J Nucl Med. 2013; 3(1): 37-43.


Vancouver/ICMJE Style

Memon SA, Laghari NA, Qureshi ST, Ahmad F, Masood A, Iqba S. Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pak J Nucl Med. (2013), [cited June 29, 2026]; 3(1): 37-43.


Harvard Style

Memon, S. A., Laghari, . N. A., Qureshi, . S. T., Ahmad, . F., Masood, . A. & Iqba, . S. (2013) Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pak J Nucl Med, 3 (1), 37-43.


Turabian Style

Memon, Sajjad Ahmed, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, and Shahid Iqba. 2013. Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pakistan Journal of Nuclear Medicine, 3 (1), 37-43.


Chicago Style

Memon, Sajjad Ahmed, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, and Shahid Iqba. "Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate." Pakistan Journal of Nuclear Medicine 3 (2013), 37-43.


MLA (The Modern Language Association) Style

Memon, Sajjad Ahmed, Naeem Ahmed Laghari, Sadaf Tabasum Qureshi, Fayaz Ahmad, Atif Masood, and Shahid Iqba. "Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate." Pakistan Journal of Nuclear Medicine 3.1 (2013), 37-43. Print.


APA (American Psychological Association) Style

Memon, S. A., Laghari, . N. A., Qureshi, . S. T., Ahmad, . F., Masood, . A. & Iqba, . S. (2013) Study of normal biodistribution and uptake patterns of novel anticancer radiopharmaceutical complex 99mTc-Methotrexate. Pakistan Journal of Nuclear Medicine, 3 (1), 37-43.




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