E-ISSN 2305-1620 | ISSN 2221-0288
 

Commentary

Online Publishing Date:
25 / 09 / 2023

 


Title: Clinical utility of BRAF and pTERT mutations in precision management of Papillary thyroid cancer

Hamid Shabbir, Muhammad Babar Imran, Muhammad Naeem.


Abstract
Papillary thyroid cancer (PTC) is the most prevalent and indolent thyroid cancer, but still, around 20% of cases will develop regional recurrence or distant metastasis. Isolated or coexistent BRAF V600E and pTERT mutations in thyroid cancer are associated with poor clinical outcomes. The prior knowledge of BRAF V600E and pTERT mutation may help to identify the cases that may recur or become refractory to standard radioactive iodine treatment. Such cases could be treated initially with complete disease eradication through extensive surgery followed by maximum permissible high-dose radioactive I-131 ablation and vigilant follow-up. Conventional risk assessment coupled with genotype-based risk assessment can help in the precise management of aggressive thyroid cancers.

Key words: BRAF, TERT, Thyroid Cancer, precision management, molecular.


 
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How to Cite this Article
Pubmed Style

Shabbir H, Imran MB, Naeem M. Title: Clinical utility of BRAF and pTERT mutations in precision management of Papillary thyroid cancer. Pak J Nucl Med. 2023; 13(1): 8-12. doi:10.24911/PJNMed.175-1672931077


Web Style

Shabbir H, Imran MB, Naeem M. Title: Clinical utility of BRAF and pTERT mutations in precision management of Papillary thyroid cancer. https://www.pjnmed.com/?mno=136845 [Access: February 27, 2024]. doi:10.24911/PJNMed.175-1672931077


AMA (American Medical Association) Style

Shabbir H, Imran MB, Naeem M. Title: Clinical utility of BRAF and pTERT mutations in precision management of Papillary thyroid cancer. Pak J Nucl Med. 2023; 13(1): 8-12. doi:10.24911/PJNMed.175-1672931077



Vancouver/ICMJE Style

Shabbir H, Imran MB, Naeem M. Title: Clinical utility of BRAF and pTERT mutations in precision management of Papillary thyroid cancer. Pak J Nucl Med. (2023), [cited February 27, 2024]; 13(1): 8-12. doi:10.24911/PJNMed.175-1672931077



Harvard Style

Shabbir, H., Imran, . M. B. & Naeem, . M. (2023) Title: Clinical utility of BRAF and pTERT mutations in precision management of Papillary thyroid cancer. Pak J Nucl Med, 13 (1), 8-12. doi:10.24911/PJNMed.175-1672931077



Turabian Style

Shabbir, Hamid, Muhammad Babar Imran, and Muhammad Naeem. 2023. Title: Clinical utility of BRAF and pTERT mutations in precision management of Papillary thyroid cancer. Pakistan Journal of Nuclear Medicine, 13 (1), 8-12. doi:10.24911/PJNMed.175-1672931077



Chicago Style

Shabbir, Hamid, Muhammad Babar Imran, and Muhammad Naeem. "Title: Clinical utility of BRAF and pTERT mutations in precision management of Papillary thyroid cancer." Pakistan Journal of Nuclear Medicine 13 (2023), 8-12. doi:10.24911/PJNMed.175-1672931077



MLA (The Modern Language Association) Style

Shabbir, Hamid, Muhammad Babar Imran, and Muhammad Naeem. "Title: Clinical utility of BRAF and pTERT mutations in precision management of Papillary thyroid cancer." Pakistan Journal of Nuclear Medicine 13.1 (2023), 8-12. Print. doi:10.24911/PJNMed.175-1672931077



APA (American Psychological Association) Style

Shabbir, H., Imran, . M. B. & Naeem, . M. (2023) Title: Clinical utility of BRAF and pTERT mutations in precision management of Papillary thyroid cancer. Pakistan Journal of Nuclear Medicine, 13 (1), 8-12. doi:10.24911/PJNMed.175-1672931077





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