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Original Article 


Bone SPECT-CT in the diagnosis and staging of osseous metastases

Sonya Sergieva, Elena Alexandrova, Bojil Robev, Iglika Mihaylova, Milena Dimcheva.


Abstract
Aims: The combined application of baseline whole-body bone scan (WBBS), followed by more specific techniques such as SPECT-CT fusion is an advanced approach for the diagnosis, differential diagnosis and staging of osseous metastases. The purpose of this work was to assess SPECT-CT images in diagnosis of suspected bone metastases in patients with oncological diseases.

Methods: This study included 89 patients (54 females, 35 males aged 18-92 yrs) with different types of tumours. All patients underwent routine WBBS with 99mTc-MDP as well as target SPECT-CT imaging using a double-headed SPECT-CT camera coupled with a 2-slice CT scanner.

Results: The skeletal findings with previously uncertain character were classified as definitely benign, indeterminate or definitely malignant. These included: 1) 33% benign degenerative lesions, 2) 28% single osseous metastases, 3) 10% direct bone infiltration, 4) 15% cold or osteolytic bone lesions, 5) 12% mixed type lesions and 6) 2% single extraosseous lesions.

Conclusion: The most important clinical application of bone SPECT-CT imaging is for differential diagnosis between degenerative and metastatic foci with abnormal tracer uptake and similar scintigraphic appearance on the WBBS.


 
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How to Cite this Article
Pubmed Style

Sergieva S, Alexandrova E, Robev B, Mihaylova I, Dimcheva M. Bone SPECT-CT in the diagnosis and staging of osseous metastases. Pak J Nucl Med. 2015; 5(1): 37-44.

Web Style

Sergieva S, Alexandrova E, Robev B, Mihaylova I, Dimcheva M. Bone SPECT-CT in the diagnosis and staging of osseous metastases. https://www.pjnmed.com/?mno=284633 [Access: June 28, 2026].

AMA (American Medical Association) Style

Sergieva S, Alexandrova E, Robev B, Mihaylova I, Dimcheva M. Bone SPECT-CT in the diagnosis and staging of osseous metastases. Pak J Nucl Med. 2015; 5(1): 37-44.


Vancouver/ICMJE Style

Sergieva S, Alexandrova E, Robev B, Mihaylova I, Dimcheva M. Bone SPECT-CT in the diagnosis and staging of osseous metastases. Pak J Nucl Med. (2015), [cited June 28, 2026]; 5(1): 37-44.


Harvard Style

Sergieva, S., Alexandrova, . E., Robev, . B., Mihaylova, . I. & Dimcheva, . M. (2015) Bone SPECT-CT in the diagnosis and staging of osseous metastases. Pak J Nucl Med, 5 (1), 37-44.


Turabian Style

Sergieva, Sonya, Elena Alexandrova, Bojil Robev, Iglika Mihaylova, and Milena Dimcheva. 2015. Bone SPECT-CT in the diagnosis and staging of osseous metastases. Pakistan Journal of Nuclear Medicine, 5 (1), 37-44.


Chicago Style

Sergieva, Sonya, Elena Alexandrova, Bojil Robev, Iglika Mihaylova, and Milena Dimcheva. "Bone SPECT-CT in the diagnosis and staging of osseous metastases." Pakistan Journal of Nuclear Medicine 5 (2015), 37-44.


MLA (The Modern Language Association) Style

Sergieva, Sonya, Elena Alexandrova, Bojil Robev, Iglika Mihaylova, and Milena Dimcheva. "Bone SPECT-CT in the diagnosis and staging of osseous metastases." Pakistan Journal of Nuclear Medicine 5.1 (2015), 37-44. Print.


APA (American Psychological Association) Style

Sergieva, S., Alexandrova, . E., Robev, . B., Mihaylova, . I. & Dimcheva, . M. (2015) Bone SPECT-CT in the diagnosis and staging of osseous metastases. Pakistan Journal of Nuclear Medicine, 5 (1), 37-44.




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