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Original Article 


Frequency of cisplatin-induced severe renal injury in patients with solid tumours on renal scintigraphy

Muhammad Inamullah, Mujahid Khalid Ali, Syed Mehdi Raza, Ehsan Mehmood, Zeeshan Ahmad Alvi.


Abstract
Objective: Cisplatin is an effective chemotherapeutic drug for the treatment of solid tumours. However, its nephrotoxic side effects limit its optimal use and renal scintigraphy may be a reliable diagnostic tool for detecting, evaluating, and quantifying any cisplatin-induced nephrotoxicity. This crosssectional retrospective study was designed to determine the frequency of cisplatin-induced severe renal injury by radionuclide renal scintigraphy in patients with solid tumours undergoing chemotherapy with cisplatin-based regimens. The at the Nuclear Medical Centre, Armed Forces Institute of Pathology (AFIP).

Methods: 62 patients (48 male, 14 female) who were candidates for cisplatin-based chemotherapy and had normal renal function as evidenced by normal serum urea and creatinine levels and a normal value of ageadjusted GFR on 99mTc-99m-DTPA renal scintigraphy as per guidelines of National kidney Foundation, were subjected to post chemotherapy 99mTc-DTPA renal scintigraphy within 02 weeks of completion of 06 cycles cisplatin-based chemotherapy.

Results: The frequency of severe renal injury was calculated as 2/62 (3.2%) as determined by 99mTc-DTPA scintigraphy after completion of 6 cycles of chemotherapy

Conclusion: 3.2% of all patients developed severe renal injury at the completion of 6 cycles of cisplatin based chemotherapeutic regimen. This included patients with severe renal injury (GFR 15-29 ml/min) as well as patients with severe renal injury leading to absolute renal failure (GFR < 15 ml/min).


 
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How to Cite this Article
Pubmed Style

Inamullah M, Ali MK, Raza SM, Mehmood E, Alvi ZA. Frequency of cisplatin-induced severe renal injury in patients with solid tumours on renal scintigraphy. Pak J Nucl Med. 2015; 5(1): 51-57.

Web Style

Inamullah M, Ali MK, Raza SM, Mehmood E, Alvi ZA. Frequency of cisplatin-induced severe renal injury in patients with solid tumours on renal scintigraphy. https://www.pjnmed.com/?mno=284641 [Access: June 30, 2026].

AMA (American Medical Association) Style

Inamullah M, Ali MK, Raza SM, Mehmood E, Alvi ZA. Frequency of cisplatin-induced severe renal injury in patients with solid tumours on renal scintigraphy. Pak J Nucl Med. 2015; 5(1): 51-57.


Vancouver/ICMJE Style

Inamullah M, Ali MK, Raza SM, Mehmood E, Alvi ZA. Frequency of cisplatin-induced severe renal injury in patients with solid tumours on renal scintigraphy. Pak J Nucl Med. (2015), [cited June 30, 2026]; 5(1): 51-57.


Harvard Style

Inamullah, M., Ali, . M. K., Raza, . S. M., Mehmood, . E. & Alvi, . Z. A. (2015) Frequency of cisplatin-induced severe renal injury in patients with solid tumours on renal scintigraphy. Pak J Nucl Med, 5 (1), 51-57.


Turabian Style

Inamullah, Muhammad, Mujahid Khalid Ali, Syed Mehdi Raza, Ehsan Mehmood, and Zeeshan Ahmad Alvi. 2015. Frequency of cisplatin-induced severe renal injury in patients with solid tumours on renal scintigraphy. Pakistan Journal of Nuclear Medicine, 5 (1), 51-57.


Chicago Style

Inamullah, Muhammad, Mujahid Khalid Ali, Syed Mehdi Raza, Ehsan Mehmood, and Zeeshan Ahmad Alvi. "Frequency of cisplatin-induced severe renal injury in patients with solid tumours on renal scintigraphy." Pakistan Journal of Nuclear Medicine 5 (2015), 51-57.


MLA (The Modern Language Association) Style

Inamullah, Muhammad, Mujahid Khalid Ali, Syed Mehdi Raza, Ehsan Mehmood, and Zeeshan Ahmad Alvi. "Frequency of cisplatin-induced severe renal injury in patients with solid tumours on renal scintigraphy." Pakistan Journal of Nuclear Medicine 5.1 (2015), 51-57. Print.


APA (American Psychological Association) Style

Inamullah, M., Ali, . M. K., Raza, . S. M., Mehmood, . E. & Alvi, . Z. A. (2015) Frequency of cisplatin-induced severe renal injury in patients with solid tumours on renal scintigraphy. Pakistan Journal of Nuclear Medicine, 5 (1), 51-57.




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