E-ISSN 2305-1620 | ISSN 2221-0288
 

Original Research (Original Article) 


Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer

Nigora Rasulova, Dauranbek Arybzhanov, Vladimir Lyubshin, Abdulla Abdikhakimov, Shamsutdin Sagdullaev,Sherzod Nishonov, Gayrat Arifhodjaev,Yuliya Shakirova, Valery Krylov, Marat Khodjibekov.

Abstract
Aims: The purpose of this study was to investigate a possible role of serum LDH as a predictor of cancer cell activity and to determine if serum LDH levels can prognosticate the duration of pain-free period after radionuclide therapy. <br> Methods: The We selected 62 breast cancer patients with ages ranging from 29-67 years (mean age 53.2 ± 9.5 years) who had a successful response to radionuclide therapy with 153Sm-oxabifore and had their serum LDH levels determined prior to the therapy. Patients with a history of a benign disease, which could possibly influence the serum LDH levels, or those suffering from complications such as a vertebral fracture or impending cord compression, were excluded from the study. <sup>153</sup>Sm-oxabifore was administrated in a standard dose of 37 MBq per kg body weight. All patients were on bisphosphonate therapy, both before and after samarium-153 treatment. Group 1 comprised of 23 patients who had received combined <sup>153</sup>Sm-oxabifore and zoledronic acid therapy. Group 2 comprised of 39 patients who had additionally received therapy for their primary tumour. For each of these two groups, the correlation between serum LDH levels and duration of the pain-free syndrome was estimated. <br> Results: There was a strong negative correlation (r = -0.84) between the serum LDH levels and the duration of pain-free period in Group 1, but no significant correlation (r = 0.1) was seen between the LDH levels and the duration of pain-free period in Group 2. The duration of pain-free period in the second group was longer in comparison to the first group and was statistically significant (p < 0.0001). <br> Conclusion: Serum LDH level can prognosticate the duration of the pain-free period after radionuclide therapy and could be useful in selecting patients who in addition to samarium-153 therapy may additionally benefit from treatment of the primary tumour.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Nigora Rasulova
Articles by Dauranbek Arybzhanov
Articles by Vladimir Lyubshin
Articles by Abdulla Abdikhakimov
Articles by Shamsutdin Sagdullaev
Articles by Sherzod Nishonov
Articles by Gayrat Arifhodjaev
Articles by Yuliya Shakirova
Articles by Valery Krylov
Articles by Marat Khodjibekov
on Google
on Google Scholar
Article Statistics
 Viewed: 933
Downloaded: 87
Cited: 0

How to Cite this Article
Pubmed Style

Rasulova N, Arybzhanov D, Lyubshin V, Abdikhakimov A, Sagdullaev S, Nishonov S, Arifhodjaev G, Shakirova Y, Krylov V, Khodjibekov M. Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer. Pak J Nucl Med. 2016; 6(1): 11-18.


Web Style

Rasulova N, Arybzhanov D, Lyubshin V, Abdikhakimov A, Sagdullaev S, Nishonov S, Arifhodjaev G, Shakirova Y, Krylov V, Khodjibekov M. Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer. http://www.pjnmed.com/?mno=284644 [Access: August 18, 2018].


AMA (American Medical Association) Style

Rasulova N, Arybzhanov D, Lyubshin V, Abdikhakimov A, Sagdullaev S, Nishonov S, Arifhodjaev G, Shakirova Y, Krylov V, Khodjibekov M. Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer. Pak J Nucl Med. 2016; 6(1): 11-18.



Vancouver/ICMJE Style

Rasulova N, Arybzhanov D, Lyubshin V, Abdikhakimov A, Sagdullaev S, Nishonov S, Arifhodjaev G, Shakirova Y, Krylov V, Khodjibekov M. Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer. Pak J Nucl Med. (2016), [cited August 18, 2018]; 6(1): 11-18.



Harvard Style

Rasulova, N., Arybzhanov, D., Lyubshin, V., Abdikhakimov, A., Sagdullaev, S., Nishonov, S., Arifhodjaev, G., Shakirova, Y., Krylov, V. & Khodjibekov, M. (2016) Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer. Pak J Nucl Med, 6 (1), 11-18.



Turabian Style

Rasulova, Nigora, Dauranbek Arybzhanov, Vladimir Lyubshin, Abdulla Abdikhakimov, Shamsutdin Sagdullaev, Sherzod Nishonov, Gayrat Arifhodjaev, Yuliya Shakirova, Valery Krylov, and Marat Khodjibekov. 2016. Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer. Pakistan Journal of Nuclear Medicine, 6 (1), 11-18.



Chicago Style

Rasulova, Nigora, Dauranbek Arybzhanov, Vladimir Lyubshin, Abdulla Abdikhakimov, Shamsutdin Sagdullaev, Sherzod Nishonov, Gayrat Arifhodjaev, Yuliya Shakirova, Valery Krylov, and Marat Khodjibekov. "Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer." Pakistan Journal of Nuclear Medicine 6 (2016), 11-18.



MLA (The Modern Language Association) Style

Rasulova, Nigora, Dauranbek Arybzhanov, Vladimir Lyubshin, Abdulla Abdikhakimov, Shamsutdin Sagdullaev, Sherzod Nishonov, Gayrat Arifhodjaev, Yuliya Shakirova, Valery Krylov, and Marat Khodjibekov. "Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer." Pakistan Journal of Nuclear Medicine 6.1 (2016), 11-18. Print.



APA (American Psychological Association) Style

Rasulova, N., Arybzhanov, D., Lyubshin, V., Abdikhakimov, A., Sagdullaev, S., Nishonov, S., Arifhodjaev, G., Shakirova, Y., Krylov, V. & Khodjibekov, M. (2016) Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer. Pakistan Journal of Nuclear Medicine, 6 (1), 11-18.





Most Viewed Articles
  • Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer
    Nigora Rasulova, Dauranbek Arybzhanov, Vladimir Lyubshin, Abdulla Abdikhakimov, Shamsutdin Sagdullaev,Sherzod Nishonov, Gayrat Arifhodjaev,Yuliya Shakirova, Valery Krylov, Marat Khodjibekov
    Pak J Nucl Med. 2016; 6(1): 11-18
    » Abstract

  • Radiosynoviorthesis in pigmented villonodular synovitis using Re-188 labelled tin colloid: a case report
    Aakif U Khan, Hameedullah, Abdul Saeed Shah, Muhammad Rauf Khattak
    Pak J Nucl Med. 2016; 6(1): 42-47
    » Abstract

  • Whither Nuclear Medicine Training in Pakistan?
    Durr-e-Sabih
    Pak J Nucl Med. 2016; 6(1): 1-2
    » Abstract

  • Multifocal osteomyelitis on bone scan performed for mandibular mass with uncertain malignancy
    Salah Oueriagli Nabih, Hassna El Guerrouj, Imad Ghfir, Nouzha Ben Raïs
    Pak J Nucl Med. 2016; 6(1): 72-74
    » Abstract

  • Functional ectopic cystic parathyroid adenomas: case reports and literature review
    Nigora Rasulova, Qaisar Hussain Siraj, Amir Javaid, Anwar Al-Banna
    Pak J Nucl Med. 2016; 6(1): 63-68
    » Abstract

  • Unusual spinal metastases from an adenoid cystic carcinoma of the maxillary sinus seen on a bone scan: a case report
    O Ait Sahel, I Ghfir, H Guerrouj, Y Benameur, N Benraiss
    Pak J Nucl Med. 2016; 6(1): 48-52
    » Abstract

  • Unsuspected chronic multifocal osteomyelitis diagnosed on a whole-body 18F-FDG PET/CT scan
    Qaisar Hussain Siraj, Amir Javaid, Khattab Khaled, Anwar Al-Banna
    Pak J Nucl Med. 2016; 6(1): 75-78
    » Abstract

  • SPECT/CT imaging of primary mediastinal goitre: case report and literature review
    Imad Ghfir, Abdallah Achir, Hasnae Guerrouj, Salah Nabih Oueriagli, Omar Ait Sahel, N Benraïs Aouad
    Pak J Nucl Med. 2016; 6(1): 53-58
    » Abstract

  • Estimation of time for release of patients after the administration of I-131 to thyrotoxicosis patients
    Muhammad Akhtar, Jawad Akhtar Hussain, Akbar Ali, Sheraz Akhtar
    Pak J Nucl Med. 2016; 6(1): 3-10
    » Abstract

  • Assessment of renal parenchymal damage by DMSA after PCNL procedure in children using adult-sized equipment
    Mohammad Sohaib, Manoj U Shenoy, Michael J Kellett, Patrick G Duffy, Isky Gordon
    Pak J Nucl Med. 2016; 6(1): 19-24
    » Abstract

  • Most Downloaded
  • SPECT/CT imaging of primary mediastinal goitre: case report and literature review
    Imad Ghfir, Abdallah Achir, Hasnae Guerrouj, Salah Nabih Oueriagli, Omar Ait Sahel, N Benraïs Aouad
    Pak J Nucl Med. 2016; 6(1): 53-58
    » Abstract

  • Multifocal osteomyelitis on bone scan performed for mandibular mass with uncertain malignancy
    Salah Oueriagli Nabih, Hassna El Guerrouj, Imad Ghfir, Nouzha Ben Raïs
    Pak J Nucl Med. 2016; 6(1): 72-74
    » Abstract

  • Radiosynoviorthesis in pigmented villonodular synovitis using Re-188 labelled tin colloid: a case report
    Aakif U Khan, Hameedullah, Abdul Saeed Shah, Muhammad Rauf Khattak
    Pak J Nucl Med. 2016; 6(1): 42-47
    » Abstract

  • Estimation of time for release of patients after the administration of I-131 to thyrotoxicosis patients
    Muhammad Akhtar, Jawad Akhtar Hussain, Akbar Ali, Sheraz Akhtar
    Pak J Nucl Med. 2016; 6(1): 3-10
    » Abstract

  • Functional ectopic cystic parathyroid adenomas: case reports and literature review
    Nigora Rasulova, Qaisar Hussain Siraj, Amir Javaid, Anwar Al-Banna
    Pak J Nucl Med. 2016; 6(1): 63-68
    » Abstract

  • Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients
    Aniqa Jabeen, Sumaira Mushtaq, Hassan Raza, Mohammd Ali Memon
    Pak J Nucl Med. 2016; 6(1): 25-31
    » Abstract

  • Assessment of renal parenchymal damage by DMSA after PCNL procedure in children using adult-sized equipment
    Mohammad Sohaib, Manoj U Shenoy, Michael J Kellett, Patrick G Duffy, Isky Gordon
    Pak J Nucl Med. 2016; 6(1): 19-24
    » Abstract

  • Unsuspected chronic multifocal osteomyelitis diagnosed on a whole-body 18F-FDG PET/CT scan
    Qaisar Hussain Siraj, Amir Javaid, Khattab Khaled, Anwar Al-Banna
    Pak J Nucl Med. 2016; 6(1): 75-78
    » Abstract

  • Pulmonary arteriovenous malformation diagnosed on a 18F-fluorodeoxyglucose PET/CT scan
    Khattab Khaled, Amir Javaid, Qaisar Hussain Siraj
    Pak J Nucl Med. 2016; 6(1): 69-71
    » Abstract

  • Whither Nuclear Medicine Training in Pakistan?
    Durr-e-Sabih
    Pak J Nucl Med. 2016; 6(1): 1-2
    » Abstract

  • Most Cited Articles