Radioactive Iodine Therapy in Differentiated Thyroid Cancer: A Contemporary Scientific Commentary Based on the 2025 ATA Guidelines

Farkhanda Gillani; Nayyar Rubab; Warda Ahmad; Arzoo Fatima; Shazia Fatima; Muhammad Babar Imran

doi:10.24911/PJNMed.175-1775907573

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Commentary
Online Published: 26 Aug 2026

Pak J Nucl Med. 2026; 16(1): 17-21

doi: 10.24911/PJNMed.175-1775907573

Radioactive iodine therapy in differentiated thyroid cancer: a contemporary scientific commentary based on the 2025 ATA Guidelines

Farkhanda Gillani, Nayyar Rubab, Warda Ahmad, Arzoo Fatima, Shazia Fatima, Muhammad Babar Imran.

Abstract
The management of differentiated thyroid cancer (DTC) has undergone substantial refinement in recent years, and the 2025 American Thyroid Association (ATA) Guidelines represent a landmark advancement in the clinical use of radioactive iodine (RAI). ATA 2025 guidelines paved the way for paradigm shift from broader, routine ablation toward a personalized, evidence-informed strategy grounded in tumor biology, molecular profiling, and long-term outcome data. As thyroid cancer epidemiology evolves, and as molecular diagnostics become increasingly accessible, debate exists among the clinicians regarding the effective use of RAI. This extended commentary synthesizes the ATA 2025 recommendations while integrating contemporary literature to contextualize the modern role of RAI in thyroid oncology and prioritize the precision in the management of differentiated thyroid cancer with radioactive iodine.

Key words: radioactive iodine, therapy, differentiated thyroid cancer, ATA 2025

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How to Cite this Article

Pubmed Style

Gillani F, Rubab N, Ahmad W, Fatima A, Fatima S, Imran MB. Radioactive iodine therapy in differentiated thyroid cancer: a contemporary scientific commentary based on the 2025 ATA Guidelines. Pak J Nucl Med. 2026; 16(1): 17-21. doi:10.24911/PJNMed.175-1775907573

Web Style

Gillani F, Rubab N, Ahmad W, Fatima A, Fatima S, Imran MB. Radioactive iodine therapy in differentiated thyroid cancer: a contemporary scientific commentary based on the 2025 ATA Guidelines. https://www.pjnmed.com/?mno=317108 [Access: September 19, 2026]. doi:10.24911/PJNMed.175-1775907573

AMA (American Medical Association) Style

Gillani F, Rubab N, Ahmad W, Fatima A, Fatima S, Imran MB. Radioactive iodine therapy in differentiated thyroid cancer: a contemporary scientific commentary based on the 2025 ATA Guidelines. Pak J Nucl Med. 2026; 16(1): 17-21. doi:10.24911/PJNMed.175-1775907573

Vancouver/ICMJE Style

Gillani F, Rubab N, Ahmad W, Fatima A, Fatima S, Imran MB. Radioactive iodine therapy in differentiated thyroid cancer: a contemporary scientific commentary based on the 2025 ATA Guidelines. Pak J Nucl Med. (2026), [cited September 19, 2026]; 16(1): 17-21. doi:10.24911/PJNMed.175-1775907573

Harvard Style

Gillani, F., Rubab, . N., Ahmad, . W., Fatima, . A., Fatima, . S. & Imran, . M. B. (2026) Radioactive iodine therapy in differentiated thyroid cancer: a contemporary scientific commentary based on the 2025 ATA Guidelines. Pak J Nucl Med, 16 (1), 17-21. doi:10.24911/PJNMed.175-1775907573

Turabian Style

Gillani, Farkhanda, Nayyar Rubab, Warda Ahmad, Arzoo Fatima, Shazia Fatima, and Muhammad Babar Imran. 2026. Radioactive iodine therapy in differentiated thyroid cancer: a contemporary scientific commentary based on the 2025 ATA Guidelines. Pakistan Journal of Nuclear Medicine, 16 (1), 17-21. doi:10.24911/PJNMed.175-1775907573

Chicago Style

Gillani, Farkhanda, Nayyar Rubab, Warda Ahmad, Arzoo Fatima, Shazia Fatima, and Muhammad Babar Imran. "Radioactive iodine therapy in differentiated thyroid cancer: a contemporary scientific commentary based on the 2025 ATA Guidelines." Pakistan Journal of Nuclear Medicine 16 (2026), 17-21. doi:10.24911/PJNMed.175-1775907573

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Gillani, F., Rubab, . N., Ahmad, . W., Fatima, . A., Fatima, . S. & Imran, . M. B. (2026) Radioactive iodine therapy in differentiated thyroid cancer: a contemporary scientific commentary based on the 2025 ATA Guidelines. Pakistan Journal of Nuclear Medicine, 16 (1), 17-21. doi:10.24911/PJNMed.175-1775907573

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